Department of Biological Sciences, Crystallography,
Birkbeck College,
University of London
Normally lectures will be made available at the beginning of the week. Week numbers are sequential per term. Each TERM roughly coincides with a particular module. There will be deviations for a few individual lectures, in order to pace delivery of more difficult subjects. Some "weeks" in Terms 1 and 2 have a release which is intended to be studied over a 2-week period. "Weeks" and "Lectures" in Term 3 are only nominal, as the projects are self-paced.
TERM 1 (Module 1: Fundamentals of Protein Structure and X-ray Crystallography) | ||||
---|---|---|---|---|
Week | Lecture | Topic | Lecturer responsible | |
October | ||||
1 | Introduction & Web Authoring | Overview of Protein Crystallography & Distane Learning (JMol, HTML, Images, IMS) | TEB | |
2 | Protein Structure I | Primary Structure & Amino Acid and Peptide Bond Geometry | TEB | |
3 | Protein Structure II | Non-Covalent (Non-Bonded) Interactions | TEB | |
4 | Protein Structure III | Secondary Structure & Super Secondary Structure | TEB | |
5 | Protein Structure IV | Tertiary Structure & Quaternary Structure (Point Groups) | AB | |
6 | X-Ray Diffraction I and the CCP4 Gui | Diffraction Theory (Scattering, Unit Cell, Braggs Law, Reciprocal Space, Indices, Structure Factor) | TEB | |
7 | Symmetry I | Symmetry Operations (Rotational, Translational, Screw, Symbols, Unit Cell) | TEB | |
8 | Symmetry II | Point Groups (Enantiomorphic, Polar, Laue Classes) | TEB | |
9 | Protein Crystallography I | Protein Crystallisation | AB | |
10 | Symmetry III | Space Groups (Enantiomorphic, Asymmetric Unit, P21, P212121) | TEB | |
11 | Protein Crystallography II | X-Rays, X-Ray Sources (Laboratory, Synchrotron) & X-Ray Detectors (Image Plate, CCD) | AB | |
Break | ||||
TERM 2 (Module 2: Protein Crystallography) | ||||
Week | Lecture | Topic | Lecturer responsible | |
1 | Protein Crystallography III | Data Collection (Oscillation Method) & Cryocrystallography | TEB | |
2 | Symmetry IV & Protein Crystallography IV | Extinctions, Space Group Determination & Data Processing | TEB | |
3 | Protein Crystallography V & X-Ray Diffraction II | Molecular Replacement (Rotation Function, Translation Function), Patterson | TEB | |
4 | Protein Crystallography VI | Isomorphous Replacement, Patterson | AB | |
5 | Protein Crystallography VII & X-Ray Diffraction III | MAD, Anomalous Diffraction | ARC | |
6 | Protein Crystallography VIII | Density Modification | TEB | |
7 | Protein Crystallography IX | Electron Density Map, Modelling & Refinement | TEB | |
8 | Protein Crystallography X | Validation & PDB | TEB | |
Break | ||||
August | WRITTEN EXAMINATIONS | |||
by Christmas | GRADES MADE AVAILABLE | |||